10206. Sacrosidase

Nomenclature

CAS number: 85897-35-4
β-Fructofuranosidase (Saccharomyces cerevisiae clone FI4 protein moiety reduced); β-d-fructofuranoside fructohydrolase; Sucraid (QOL Medical).

Description and references

Form of sucrase (invertase) produced by baker's yeast, Saccharomyces cerevesiae. Glycosylated peptide containing 513 amino acid residues; mol wt 66-116 kDa. Hydrolyzes sucrose into glucose and fructose. Purification and properties of natural yeast invertase: N. P. Neumann, J. O. Lampen, Biochemistry 6, 468 (1967) DOI PubMed. Prepn by clone FI4: C. N. Chang et al., US 5010003 (1991 to Genentech). Clinical trial in congenital sucrase-isomaltase deficiency: W. R. Treem et al., J. Pediatr. Gastroenterol. Nutr. 28, 137 (1999) DOI PubMed.

Properties

May exist in soln as monomer, dimer, tetramer, and octomer. pI 4.093. Protect from heat and light.

Therapeutic Category

Enzyme replacement therapy (congenital sucrase-isomaltase deficiency).

Keywords

Enzyme Replacement Therapy