10238. Fesoterodine

Nomenclature

CAS number: 286930-02-7
2-Methylpropanoic acid 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester; 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate; (R)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenylisobutyrate ester.
C26H37NO3; mol wt 411.58.
C 75.87%, H 9.06%, N 3.40%, O 11.66%.

Description and references

Muscarinic M3-receptor antagonist. Prepn: B. Sparf, C. O. Meese, EP 0957073; eidem, US 6713464 (1999, 2004 both to Schwarz). Prepn of stable salts: C. Meese, DE 19955190; idem, US 6858650 (2001, 2005 both to Schwarz). Clinical trial in overactive bladder: C. Chapple et al., Eur. Urol. 52, 1204 (2007) DOI PubMed.

Chemical structure

Properties

Colorless, viscous oil.

Derivative

Fumarate.

Nomenclature

CAS number: 286930-03-8
SPM-907; SPM-8272; Toviaz (Pfizer).
C26H37NO3.C4H4O4; mol wt 527.65.
C 68.29%, H 7.83%, N 2.65%, O 21.23%.

Properties

Colorless flakes from cyclohexane/2-butanone (90:10), mp 103°. Absorption max: 191, 193, 200, 220 nm (A1cm1% 1306, 1305, 1143, 456).

Therapeutic Category

Antispasmodic; in treatment of overactive bladder.

Keywords

Antimuscarinic; Antispasmodic