Human monoclonal antibody directed against the shared p40 subunit of interleukins IL-12 and IL-23. Prepn: J. Giles-Komar et al., WO 0212500; eidem, US 6902734 (2002, 2005 both to Centocor). Pharmacology: M. Reddy et al., Cell. Immunol. 247, 1 (2007) DOI PubMed. Clinical pharmacokinetics: C. L. Kauffman et al., J. Invest. Dermatol. 123, 1037 (2004) DOI PubMed. Clinical trials in psoriasis: C. L. Leonardi et al., Lancet 371, 1665 (2008) DOI PubMed; K. A. Papp et al., ibid. 1675 DOI PubMed.
Antipsoriatic; immunomodulator.
Antipsoriatic; Immunomodulator