10374. Mecasermin

Nomenclature

CAS number: 68562-41-4
Insulin-like growth factor I (human); rhIGF-1; Increlex (Tercica).
C331H512N94O101S7; mol wt 7648.63.
C 51.98%, H 6.75%, N 17.21%, O 21.13%, S 2.93%.

Description and references

Recombinant human form of insulin-like growth factor I (IGF-I) produced in E. coli; has the same amino acid sequence as the endogenous form. Prepn: J. M. Lee, A. Ulrich, EP 128733 (1984 to Genentech). Pharmaceutical formulation: R. G. Clark et al., US 5681814 (1997 to Genentech). Review of clinical experience: P. Norman, Curr. Opin. Investig. Drugs 7, 371-380 (2006) PubMed; A. L. Rosenbloom, Adv. Ther. 26, 40-54 (2009) DOI PubMed.

Therapeutic Category

Treatment of growth failure in children.