Recombinant human insulin-like growth factor I (IGF-I) complexed with its principle binding protein, IGFB-3, in equimolar amounts. The two proteins are produced separately by 2 strains of E. coli, purified, and combined into a 1:1 complex. Preparative method and use in promoting bone formation: C. M. Bagi et al., US 6017885 (2000 to Celtrix). Musculoskeletal effects in osteoporotic patients: S. Boonen et al., J. Clin. Endocrinol. Metab. 87, 1593 (2002) DOI PubMed. Review of pharmacology and clinical experience: P. Norman, Curr. Opin. Investig. Drugs 4, 466-471 (2003) PubMed; R. M. Williams et al., Expert Opin. Drug Metab. Toxicol. 4, 311-324 (2008) DOI PubMed.
In treatment of amyotrophic lateral sclerosis.