10375. Dirucotide

Nomenclature

CAS number: 152074-97-0
l-α-Aspartyl-l-α-glutamyl-l-asparaginyl-l-prolyl-l-valyl-l-valyl-l-histidyl-l-phenylalanyl-l-phenylalanyl-l-lysyl-l-asparaginyl-l-isoleucyl-l-valyl-l-threonyl-l-prolyl-l-arginyl-l-threonine; MBP-8298; SF-328.
C92H141N25O26; mol wt 2013.26.
C 54.89%, H 7.06%, N 17.39%, O 20.66%.
DENPVVHFFKNIVTPRT.

Description and references

Synthetic peptide corresponding to residues 82 to 98 of human myelin basic protein (MBP); suppresses the autoimmune response directed against MBP in multiple sclerosis. Prepn: K. G. Warren, I. Catz, WO 9308212 (1993); H. L. Weiner et al., WO 9321222; eidem, US 5858980 (1993, 1999 both to Autoimmune). Structure-activity study: K. W. Wucherpfennig et al., J. Exp. Med. 179, 279 (1994) DOI PubMed. Tolerance induction in MS patients: K. G. Warren et al., J. Neurol. Sci. 152, 31 (1997) DOI PubMed. Clinical trial in multiple sclerosis: idem et al., Eur. J. Neurol. 13, 887 (2006) DOI PubMed. Review: C. Darlington, Curr. Opin. Mol. Ther. 9, 398-402 (2007) PubMed.

Chemical structure

Therapeutic Category

Immunomodulator; in treatment of multiple sclerosis.

Keywords

Immunomodulator