10217. Dirlotapide
Nomenclature
CAS number: 481658-94-0
1-Methyl-N-[(1S)-2-[methyl(phenylmethyl)amino]-2-oxo-1-phenylethyl]-5-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-1H-indole-2-carboxamide; (S)-N-[2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[4′-(trifluoromethyl)[1,1′-biphenyl]-2-carboxamido]-1H-indole-2-carboxamide; 5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide; CP-742033; Slentrol (Pfizer Animal Health). C40H33F3N4O3; mol wt 674.71.
C 71.21%, H 4.93%, F 8.45%, N 8.30%, O 7.11%.
Description and references
Microsomal triglyceride transfer protein inhibitor; blocks the assembly and release of lipoprotein particles into the bloodstream. Prepn: P. Bertinato et al., WO 03002533; eidem, US 6720351 (2003, 2004 both to Pfizer); and pharmacology: J. Li et al., Bioorg. Med. Chem. Lett. 17, 1996 (2007) DOI PubMed.
