10385. Pazopanib

Nomenclature

CAS number: 444731-52-6
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide; N4(2,3-dimethyl-2H-indazol-6-yl)-N4-methyl-N2-(4-methyl-3-sulfonamidophenyl)-2,4-pyrimidinediamine; GW-786034.
C21H23N7O2S; mol wt 437.52.
C 57.65%, H 5.30%, N 22.41%, O 7.31%, S 7.33%.

Description and references

Multitargeted tyrosine kinase inhibitor with antiangiogenic activity. Prepn: A. Boloor et al., WO 02059110 (2002 to Glaxo); eidem, US 7105530 (2006 to SKB); P. A. Harris et al., J. Med. Chem. 51, 4632 (2008) DOI PubMed. Pharmacology: R. Kumar et al., Mol. Cancer Ther. 6, 2012 (2007) DOI PubMed. Review of clinical experience in renal cell carcinoma: G. Sonpavde et al., Expert Opin. Invest. Drugs 17, 253-261 (2008) DOI PubMed.

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 635702-64-6
GW-786034B.
C21H23N7O2S.HCl; mol wt 473.98.
C 53.21%, H 5.10%, N 20.69%, O 6.75%, S 6.77%, Cl 7.48%.

Properties

White solid.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Tyrosine Kinase Inhibitors