10391. Dimebolin

Nomenclature

CAS number: 3613-73-8
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole; 9-[2-(2-methyl-5-pyridinyl)ethyl]-3,6-dimethyl-1,2,3,4-tetrahydro-γ-carboline; dimebon.
C21H25N3; mol wt 319.44.
C 78.96%, H 7.89%, N 13.15%.

Description and references

γ-Carboline derivative with antihistaminic and cognition enhancing activity. Prepn: A. N. Kost et al., Zh. Obshch. Khim. 32, 2050 (1962), C.A. 58, 7917d. Pharmacology: S. K. Shadurskaya et al., Bull. Exp. Biol. Med. 101, 780 (1986); S. Bachurin et al., Ann. N.Y. Acad. Sci. 939, 425 (2001) DOI PubMed. Clinical evaluation in Alzheimer's disease: R. S. Doody et al., Lancet 372, 207 (2008) DOI PubMed.

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 97657-92-6
C21H25N3.2HCl; mol wt 392.37.
C 64.28%, H 6.94%, N 10.71%, Cl 18.07%.

Properties

mp 220-222°.

Therapeutic Category

Antihistaminic; nootropic.