12-00514. Amixetrine [Archived]

Nomenclature

CAS number: 24622-72-8
1-[2-(3-Methylbutoxy)-2-phenylethyl]pyrrolidine; 1-[β-(isopentyloxy)phenethyl]pyrrolidine; N-(2-phenyl-2-isoamyloxy)ethylpyrrolidine.
C17H27NO; mol wt 261.40.
C 78.11%, H 10.41%, N 5.36%, O 6.12%.

Description and references

Prepn by reacting styrene and isoamyl alcohol with t-butyl hypobromite and then condensing the product with pyrrolidine: Mauvernay, Busch, DE 1811767 (1969 to C.E.R.M.), C.A. 72, 21607e (1970). Identification of urinary metabolites in humans and dogs: M. Constantin et al., Arzneim.-Forsch. 26, 80 (1976). Pharmcokinetics: M. Constantin, J. F. Pognat, ibid. 28, 646 (1978).

Chemical structure

Properties

bp2 121°. nD21.6 1.4978.

Derivative

Hydrochloride.

Nomenclature

CAS number: 24622-52-4
Somagest (Riom).
C17H27NO.HCl; mol wt 297.86.
C 68.55%, H 9.48%, N 4.70%, O 5.37%, Cl 11.90%.

Properties

Crystals, mp 150°.

Therapeutic Category

Antispasmodic.

Status

This monograph has been retired and is no longer subject to revision or update.