12-00611. Amoproxan [Archived]

Nomenclature

CAS number: 22661-76-3
3,4,5-Trimethoxybenzoic acid 1-[(3-methylbutoxy)methyl]-2-(4-morpholinyl)ethyl ester; 3,4,5-trimethoxybenzoic acid 1-[(isopentyloxy)methyl]-2-morpholinoethyl ester; α-[(isopentyloxy)methyl]-4-morpholineethanol 3,4,5-trimethoxybenzoate; 4-[3-(isoamyloxy)-2-(3,4,5-trimethoxybenzoyloxy)propyl]tetrahydro-1,4-oxazine; 3,4,5-trimethoxybenzoic acid 2-(isopentyloxy)-1-(morpholinomethyl)ethyl ester.
C22H35NO7; mol wt 425.52.
C 62.10%, H 8.29%, N 3.29%, O 26.32%.

Description and references

Prepn: Mauvernay et al., GB 1211307 corresp to US 3781432 (1970, 1973 to C.E.R.M.) and US 3790569 (1974). Pharmacology: Duchene-Marullaz et al., Therapie 24, 665 (1969); Pernod et al., ibid. 675; Roulet et al., ibid. 27, 93 (1972).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 22661-96-7
CERM-730.
C22H35NO7.HCl; mol wt 461.98.
C 57.20%, H 7.85%, N 3.03%, O 24.24%, Cl 7.67%.

Properties

Crystals from anhydr isopropyl alcohol, mp 145°. Sol in water, alcohol; very slightly sol in ethyl acetate.

Therapeutic Category

Antiarrhythmic.

Keywords

Antiarrhythmic

Status

This monograph has been retired and is no longer subject to revision or update.