12-00610. Amolanone [Archived]

Nomenclature

CAS number: 76-65-3
3-[2-(Diethylamino)ethyl]-3-phenyl-2(3H)-benzofuranone; 3-(2-diethylaminoethyl)-2-oxo-3-phenyl-2,3-dihydrobenzofuran; γ-diethylamino-α-(o-hydroxyphenyl)-α-phenylbutyric acid lactone; amocaine; AP-43.
C20H23NO2; mol wt 309.40.
C 77.64%, H 7.49%, N 4.53%, O 10.34%.

Description and references

Prepn: Weston, Brownell, J. Am. Chem. Soc. 74, 653 (1952).

Chemical structure

Properties

Crystals from petr ether, mp 43-44°. bp2.0 192-194°. nD24.5 1.5614.

Derivative

Hydrochloride.

Nomenclature

CAS number: 6009-67-2
C20H23NO2.HCl; mol wt 345.86.
C 69.45%, H 6.99%, N 4.05%, O 9.25%, Cl 10.25%.

Properties

Crystals from isopropanol, mp 152-153°. Sol in water.

Therapeutic Category

Anesthetic (local).

Keywords

Anesthetic (Local)

Status

This monograph has been retired and is no longer subject to revision or update.