12-00632. Amprotropine Phosphate [Archived]

Nomenclature

CAS number: 134-53-2
α-(Hydroxymethyl)benzeneacetic acid 3-(diethylamino)-2,2-dimethylpropyl ester phosphate (1:1) salt; 3-diethylamino-2,2-dimethylpropyl tropate phosphate; Syntropan (Roche).
C18H32NO7P; mol wt 405.42.
C 53.33%, H 7.96%, N 3.45%, O 27.62%, P 7.64%.

Description and references

Anticholinergic. Prepn: US 1932341 (1933); US 1987546 (1935).

Chemical structure

Properties

Bitter crystals, mp 142-145°. Freely sol in water; slightly sol in abs alcohol. Insol in chloroform, ether. The aq soln is acid to litmus.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic

Status

This monograph has been retired and is no longer subject to revision or update.