12-02608. Corycavidine [Archived]

Nomenclature

CAS number: 521-93-7
(15R)-5,7,8,15-Tetrahydro-3,4-dimethoxy-6,15-dimethyl-[1,3]benzodioxolo[5,6-e][2]benzazecin-14(6H)-one.
C22H25NO5; mol wt 383.44.
C 68.91%, H 6.57%, N 3.65%, O 20.86%.

Description and references

In Corydalis cava (L.) Schweigg & Korte (C. tuberosa DC.), Fumariaceae: Gadamer, Arch. Pharm. 249, 30 (1911); von Bruchhausen, ibid. 263, 570 (1925). Synthesis of dl-form: Govindachari, Rajadurai, J. Sci. Ind. Res. 16B, 506 (1957).

Chemical structure

Properties

Crystals from methanol, mp 212°. [α]D20 +211°. Unstable to light; racemizes at the mp.

Derivative

dl-Form.

Properties

Prisms from ether, mp 194°.

Derivative

Hydrochloride.
C22H25NO5.HCl; mol wt 419.90.
C 62.93%, H 6.24%, N 3.34%, O 19.05%, Cl 8.44%.

Properties

Crystals, easily sol in water and alcohol.

Status

This monograph has been retired and is no longer subject to revision or update.