12-02620. Cotoin [Archived]

Nomenclature

CAS number: 479-21-0
(2,6-Dihydroxy-4-methoxyphenyl)phenylmethanone; 2,6-dihydroxy-4-methoxybenzophenone.
C14H12O4; mol wt 244.24.
C 68.85%, H 4.95%, O 26.20%.

Description and references

Crystalline principle from true coto bark, the bark of Aniba coto (Rusby) Kost, Lauraceae. Extraction procedure: Jobst, Hesse, Ann. 199, 17 (1879). Isoln from South American rosewood trees, Aniba rosaeodora Ducke and A. duckei Kost. Lauraceae: Gottlieb, Mors, J. Am. Chem. Soc. 80, 2263 (1958). Structure: Karrer, Lichtenstein, Helv. Chim. Acta 11, 789 (1928). Toxicity study: Jodbauer, Kurz, Biochem. Z. 74, 340 (1916).

Chemical structure

Properties

Yellow needles from benzene, mp 131-132°. Sharp taste. Almost insol in water. Sol in alcohol, methanol, amyl alcohol, benzene, chloroform, ether, carbon bisulfide, acetone, solns of alkali hydroxides and carbonates. Solns are yellow. Slowly reduces Fehling's soln or ammoniacal AgNO3 in the cold. LD s.c. in frogs: 8 mg/kg (Jodbauer, Kurz).

Caution

Irritates mucous membranes.

Status

This monograph has been retired and is no longer subject to revision or update.