12-02824. Cycothiamin(e) [Archived]

Nomenclature

CAS number: 6092-18-8
N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[1-(2-oxo-1,3-oxathian-4-ylidene)ethyl]formamide; carbothiamine; cyclocarbothiamine; cycotiamine; CCT; Cometamine (Yamanouchi); Commetamin.
C13H16N4O3S; mol wt 308.36.
C 50.64%, H 5.23%, N 18.17%, O 15.57%, S 10.40%.

Description and references

Prepn: NL 6511842 corresp. to Murakami et al., US 3324124 (1966, 1967 to Yamanouchi Seiyaku).

Chemical structure

Properties

Crystals from water, dec 175.5°.

Derivative

Hydrochloride.
C13H16N4O3S.HCl; mol wt 344.82.
C 45.28%, H 4.97%, N 16.25%, O 13.92%, S 9.30%, Cl 10.28%.

Properties

Crystals from methanol+ ethyl acetate, or from ethylene dichloride, dec 179-180°.

Therapeutic Category

Oral thiamine therapy.

Keywords

Enzyme Cofactor; Vitamin/Vitamin Source; Vitamin B1

Status

This monograph has been retired and is no longer subject to revision or update.