12-02825. Cycrimine Hydrochloride [Archived]

Nomenclature

CAS number: 126-02-3
α-Cyclopentyl-α-phenyl-1-piperidinepropanol hydrochloride; 1-phenyl-1-cyclopentyl-3-piperidino-1-propanol hydrochloride; compd 8958; Pagitane hydrochloride (Lilly).
C19H30ClNO; mol wt 323.90.
C 70.45%, H 9.34%, Cl 10.95%, N 4.32%, O 4.94%.

Description and references

Anticholinergic. Prepd by the addition of a Grignard reagent to the corresponding β-aminoketone: Denton et al., J. Am. Chem. Soc. 72, 3795 (1950).

Chemical structure

Properties

Crystals, dec 241-244°. Very bitter taste. Soly (g/100 ml) at 25° in water: 0.6; in ethanol: 2.0; in chloroform: 3.0. pH of a 0.5% aq soln: 4.9-5.4.

Therapeutic Category

Antiparkinsonian.

Keywords

Antiparkinsonian; Antimuscarinic

Status

This monograph has been retired and is no longer subject to revision or update.