12-03082. Dibutoline Sulfate [Archived]

Nomenclature

CAS number: 532-49-0
2-[[(Dibutylamino)carbonyl]oxy]-N-ethyl-N,N-dimethylethanaminium sulfate (2:1); bis[ethyl(2-hydroxyethyl)dimethylammonium] sulfate bis(dibutylcarbamate); (2-dibutyl-carbamyloxyethyl)dimethylethylammonium sulfate; dimethylethyl-β-hydroxyethylammonium sulfate dibutylurethan; Dibuline Sulfate (Merck & Co.).
C30H66N4O8S; mol wt 642.93.
C 56.04%, H 10.35%, N 8.71%, O 19.91%, S 4.99%.

Description and references

Anticholinergic. Prepd by treating dibutoline iodide with Ag2SO4: Swan, White, US 2408893 (1946); US 2432049 (1947).

Chemical structure

Properties

Extremely hygroscopic powder. Dec 166°. Usually furnished as a colorless aqueous soln. Also sol in benzene. A surface-active agent; a 5% aq soln (pH 6.75-7.50) has an air-water interfacial tension of 42 dynes/cm at 25°; also reported as 47 dynes/cm: Swan, White, Am. J. Ophthalmol. 27, 933 (1944). Ampuled aq solns may be stored at room temp for at least one year without precipitation, darkening, change of pH, or loss of potency. Heating of aq solns at 100° causes decompn. Sterilization by filtration is recommended.

Therapeutic Category

Antispasmodic.

Status

This monograph has been retired and is no longer subject to revision or update.