12-03318. Dimoxyline [Archived]

Nomenclature

CAS number: 147-27-3
1-(4-Ethoxy-3-methoxybenzyl)-6,7-dimethoxy-3-methylisoquinoline; 6,7-dimethoxy-3-methyl-1-(3′-methoxy-4′-ethoxybenzyl)isoquinoline; 6,7-dimethoxy-1-(4′-ethoxy-3′-methoxybenzyl)-3-methylisoquinoline; dioxyline; Paveril (Lilly).
C22H25NO4; mol wt 367.44.
C 71.91%, H 6.86%, N 3.81%, O 17.42%.

Description and references

Prepn: Shepard, US 2728769 (1955 to Lilly).

Chemical structure

Properties

Crystals from dil ethanol, mp 124-125°.

Derivative

Hydrochloride.
C22H25NO4.HCl; mol wt 403.90.
C 65.42%, H 6.49%, N 3.47%, O 15.84%, Cl 8.78%.

Properties

Crystals, dec 196-208°.

Derivative

Phosphate.

Nomenclature

CAS number: 5667-46-9
C22H25NO4.H3PO4; mol wt 465.43.
C 56.77%, H 6.06%, N 3.01%, O 27.50%, P 6.65%.

Properties

Crystals, dec 197-199°. More sol than the hydrochloride.

Therapeutic Category

Vasodilator.

Status

This monograph has been retired and is no longer subject to revision or update.