13-03294. Dimorpholamine [Archived]

Nomenclature

CAS number: 119-48-2
N,N′-1,2-Ethanediylbis[N-butyl-4-morpholinecarboxamide]; N,N′-dibutyl-N,N′-dicarboxymorpholideethylenediamine; N,N′-dibutyl-N,N′-dicarboxyethylene diaminemorpholide; TH-1064; Amipan T; Théraleptique; Theraptique.
C20H38N4O4; mol wt 398.54.
C 60.27%, H 9.61%, N 14.06%, O 16.06%.

Description and references

Prepn: Boon, J. Chem. Soc. 1947, 307; idem, US 2398283 and US 2409829 (both 1946 to I.C.I.). Toxicity data: Y. Kasé et al., Arch. Int. Pharmacodyn. Ther. 163, 133 (1966).

Chemical structure

Properties

Crystals from petr ether, mp 41-42°. bp0.4 229°. Solubility in water: 50%. LD50 in mice (mg/10 g): 0.54 i.v.; 0.80 i.p.; 1.04 s.c.; 3.80 orally (Kasé).

Therapeutic Category

Analeptic.

Keywords

Respiratory Stimulant

Status

This monograph has been retired and is no longer subject to revision or update.