12-03382. Nicofetamide [Archived]

Nomenclature

CAS number: 553-06-0
N-(1,2-Diphenylethyl)-3-pyridinecarboxamide; 1-nicotinylamino-1,2-diphenylethane; N-(1,2-diphenylethyl)nicotinamide; C-1065; Lyspamin (Bracco).
C20H18N2O; mol wt 302.37.
C 79.44%, H 6.00%, N 9.26%, O 5.29%.

Description and references

Anticholinergic. Prepn: Suter, US 2483250 (1949 to Cilag).

Chemical structure

Properties

Needles from ethanol, mp 159°. Readily sol in 5N HCl; moderately sol in methanol, acetone, ether, benzene; slightly sol in ethanol. Practically insol in water and alkalies.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic; Antimuscarinic

Status

This monograph has been retired and is no longer subject to revision or update.