12-06604. Nicofibrate [Archived]

Nomenclature

CAS number: 31980-29-7
2-(4-Chlorophenoxy)-2-methylpropanoic acid 3-pyridinylmethyl ester; 2-(p-chlorophenoxy)-2-methylpropionic acid 3-pyridylmethyl ester; 3-hydroxymethylpyridine p-chlorophenoxyisobutyrate; clofenpyride.
C16H16ClNO3; mol wt 305.76.
C 62.85%, H 5.27%, Cl 11.60%, N 4.58%, O 15.70%.

Description and references

Prepn: NL 6610738 corresp to Bolhofer, US 3369025 (1967, 1968, both to Merck & Co.); Nakanishi et al., JP 68 14466 (1968 to Yoshitomi); Garzia, DE 1948320 (1970 to Ist. Chem. Ital.). Pharmacology: Marmo et al., Farmaco Ed. Prat. 26, 557 (1971).

Chemical structure

Properties

mp 48-49°. bp0.4 180°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 17413-51-3
Arterium V (Schwarz).
C16H16ClNO3.HCl; mol wt 342.22.
C 56.15%, H 5.01%, Cl 20.72%, N 4.09%, O 14.03%.

Properties

Crystals from ethyl acetate, mp 115.5-118.5°.

Therapeutic Category

Antilipemic.

Keywords

Antihyperlipoproteinemic; Fibrates

Status

This monograph has been retired and is no longer subject to revision or update.