12-03918. Etisazol [Archived]

Nomenclature

CAS number: 7716-60-1
N-Ethyl-1,2-benzisothiazol-3-amine; 3-(ethylamino)-1,2-benzisothiazole; Netrosylla (Bayer).
C9H10N2S; mol wt 178.25.
C 60.64%, H 5.65%, N 15.72%, S 17.99%.

Description and references

Prepd by the reaction of diphenyldisulfide-2,2′-dicarbonyl dichloride with ethylamine, followed by treatment with PCl5 and ammonia: Boeshagen, Ber. 99, 2566 (1966). Chemistry studies: Geiger et al., ibid. 102, 1961 (1969); Boeshagen et al., ibid. 103, 3166 (1970).

Chemical structure

Properties

mp 78°.

Derivative

Hydrochloride.

Nomenclature

Bay Va 5387; Ectimar (Bayer).
C9H10N2S.HCl; mol wt 214.72.
C 50.34%, H 5.16%, N 13.05%, S 14.93%, Cl 16.51%.

Properties

Crystals from ethanol, mp 171°.

Therapeutic Category (Veterinary)

Antifungal.

Status

This monograph has been retired and is no longer subject to revision or update.