13-03906. Etodroxizine [Archived]

Nomenclature

CAS number: 17692-34-1
2-[2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethoxy]ethanol; 1-(p-chlorobenzhydryl)-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]piperazine; 1-(p-chloro-α-phenylbenzyl)-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]diethylenediamine; hydrochlorbenzethylamine.
C23H31ClN2O3; mol wt 418.96.
C 65.94%, H 7.46%, Cl 8.46%, N 6.69%, O 11.46%.

Description and references

Prepn: Morren, GB 817231 (1959). GC determn in plasma: R. Pentz, A. Schutt, Arch. Toxicol. 39, 225 (1978). Clinical evaluations in insomnia: R. Loire, A. Perrin, Lyon Med. 219, 1795 (1968); S. Fedeli, Brux. Med. 48, 517 (1968). Toxicology: M. Giurgea, J. Puigdevall, Proc. Eur. Soc. Study Drug Toxic. 9, 134 (1968).

Chemical structure

Properties

Liquid, bp0.01 250°.

Derivative

Dimaleate.

Nomenclature

CAS number: 56335-21-8
Indunox (UCB); Drimyl (Cassenne).
C23H31ClN2O3.2C4H4O4; mol wt 651.10.
C 57.19%, H 6.04%, Cl 5.45%, N 4.30%, O 27.03%.

Properties

LD50 orally in rats: 920 mg/kg (Giurgea, Puigdevall).

Therapeutic Category

Hypnotic.

Keywords

Sedative/Hypnotic

Status

This monograph has been retired and is no longer subject to revision or update.