12-04588. Guanazodine [Archived]

Nomenclature

CAS number: 32059-15-7
[(Octahydro-2-azocinyl)methyl]guanidine; α-guanidinomethylheptamethylenimine; 1-azacyclooct-2-ylmethylguanidine.
C9H20N4; mol wt 184.28.
C 58.66%, H 10.94%, N 30.40%.

Description and references

Hypotensive agent, related structurally to guanethidine. Prepn of the sulfate salt: J. Rakoczi et al., HU 155990; eidem, US 3856778 (1969, 1974 both to EGYT). Pharmacokinetics in man: T. Past et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 8, 111 (1973). General pharmacology: H. Iwata et al., Oyo Yakuri 14, 235 (1977), C.A. 88, 16070 (1977). Analytical study: E. Zollner-Ivan, Acta Pharm. Hung. 48, 76 (1978). Clinical studies in hypertension: S. Dobi et al., Ther. Hung. 28, 60 (1980); Z. Herpai et al., ibid. 181.

Chemical structure

Derivative

Sulfate monohydrate.

Nomenclature

EGYT-739; Calnegyt (Toyo Jozo); Sanegyt (EGYT).
C9H20N4.H2SO4.H2O; mol wt 300.38.
C 35.99%, H 8.05%, N 18.65%, S 10.67%, O 26.63%.

Properties

White crystals from water, mp 239-241°. LD50 in mice (mg/kg): 2450 orally, 700 s.c., 165 i.v. (Rakoczi, 1974).

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Guanidine Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.