12-04870. N-Hydroxyethylpromethazine Chloride [Archived]

Nomenclature

CAS number: 2090-54-2
N-(2-Hydroxyethyl)-N,N,α-trimethyl-10H-phenothiazine-10-ethanaminium chloride; (2-hydroxyethyl)dimethyl(1-methyl-2-phenothiazin-10-ylethyl)ammonium chloride; N,N-dimethyl-N-[(α-methyl-β-phenothiazin-10-yl)ethyl]-N-(β-hydroxyethyl)ammonium chloride; [1-(10-phenothiazinylmethyl)ethyl]-2-hydroxyethyldimethylammonium chloride; Aprobit.
C19H25ClN2OS; mol wt 364.93.
C 62.53%, H 6.91%, Cl 9.72%, N 7.68%, O 4.38%, S 8.79%.

Description and references

Prepd from N,N-dimethyl-N-[(α-methyl-β-phenothiazin-10-yl)ethyl]amine and glycol chlorohydrin in methyl ethyl ketone: Carlsson, Karlson, GB 881379 (1961 to Aktiebolaget Recip).

Chemical structure

Properties

Crystals from isopropanol, mp 233°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Tricyclics; Phenothiazines

Status

This monograph has been retired and is no longer subject to revision or update.