12-04878. 17-Hydroxy-16-methylene-Δ6-progesterone [Archived]

Nomenclature

CAS number: 10087-54-4
17-Hydroxy-16-methylenepregna-4,6-diene-3,20-dione; 6-dehydro-17α-hydroxy-16-methyleneprogesterone.
C22H28O3; mol wt 340.46.
C 77.61%, H 8.29%, O 14.10%.

Description and references

Prepn: Syhora, Mazac, Collect. Czech. Chem. Commun. 29, 2351 (1964). Prepn of the 17-acetate: GB 901293 (1962 to Upjohn); Syhora, Mazac, loc. cit.; GB 963427 (1964 to E. Merck).

Chemical structure

Properties

Crystals from methanol, mp 196.5-197°. [α]D20 72.5°. uv max: 283 nm (log ε 4.51).

Derivative

17-Acetate.

Nomenclature

CAS number: 805-84-5
17-Acetoxy-16-methylenepregna-4,6-diene-3,20-dione; 17α-acetoxy-6-dehydro-16-methyleneprogesterone; Superlutin.
C24H30O4; mol wt 382.49.
C 75.36%, H 7.91%, O 16.73%.

Properties

Crystals from ethyl acetate, mp 233-234°. [α]D20 132°. uv max: 283 nm (log ε 4.50).

Therapeutic Category

Progestogen (oral).

Keywords

Progestogen

Status

This monograph has been retired and is no longer subject to revision or update.