12-05118. Isaxonine [Archived]

Nomenclature

CAS number: 4214-72-6
N-(1-Methylethyl)-2-pyrimidinamine; 2-(isopropylamino)pyrimidine.
C7H11N3; mol wt 137.18.
C 61.29%, H 8.08%, N 30.63%.

Description and references

Neurotropic agent that promotes neurite outgrowth. Prepn: D. J. Brown, J. S. Harper, J. Chem. Soc. 1965, 5542. Prepn of pharmacologically active salts: A. Esanu, BE 788648; idem, US 3984414; idem, DE 2707095; idem, US 4073895 (1973, 1976, 1977, 1978 all to Soc. d'Etudes Prod. Chim.). Nerve growth promoting action: A. Hugelin et al., C.R. Seances Acad. Sci. Ser. D 285, 1339 (1977); eidem, Experientia 35, 626 (1979). Enhancement of muscle re-innervation in man: A. Sebille, A. Hugelin, Br. J. Pharmacol. 9, 275 (1980). Series of articles on in vitro effects, pharmacology, clinical studies: Nouv. Presse Med. 11, 1189-1280 (1982).

Chemical structure

Properties

mp 27-28°. bp12 92-93°.

Derivative

Phosphate.

Nomenclature

CAS number: 65606-21-5
Nerfactor (Ipsen).
C7H11N3.H3PO4; mol wt 235.18.
C 35.75%, H 6.00%, N 17.87%, P 13.17%, O 27.21%.

Properties

White crystalline powder, mp 125°. LD50 in mice (g/kg): 2.83 orally; 1.53 i.p. (Esanu, 1978).

Therapeutic Category

In treatment of peripheral neuropathies.

Status

This monograph has been retired and is no longer subject to revision or update.