12-05188. Isofezolac [Archived]

Nomenclature

CAS number: 50270-33-2
1,3,4-Triphenyl-1H-pyrazole-5-acetic acid; LM-22102; Sofenac (Rhne-Poulenc).
C23H18N2O2; mol wt 354.40.
C 77.95%, H 5.12%, N 7.90%, O 9.03%.

Description and references

Non-steroidal anti-inflammatory agent; prostaglandin synthetase inhibitor. Prepn: C. Gueremy, C. Renault, DE 2312256; eidem, US 3984431 (1973, 1976 to Société Générale de Recherches et d'Applications Scientifiques). Pharmacology: J. Mizoule et al., Arch. Int. Pharmacodyn. 238, 305 (1979). HPLC determn in biological fluids: A. Bannier et al., J. Chromatogr. 227, 213 (1982).

Chemical structure

Properties

Crystals from acetonitrile, mp 200°. LD50 in mice, rats (mg/kg): 215, 13 orally (Mizoule).

Therapeutic Category

Anti-inflammatory; antipyretic; analgesic.

Keywords

Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives; Antipyretic

Status

This monograph has been retired and is no longer subject to revision or update.