13-05196. Isoladol [Archived]
Nomenclature
CAS number: 530-34-7
β-Amino-4-methoxy-α-(4-methoxyphenyl)benzeneethanol; 2-amino-1,2-bis(p-methoxyphenyl)ethanol; isodianisylethanolamine; di-p-methoxyphenylhydroxyethylamine; Evadol (Clin-Comar-Byla). C16H19NO3; mol wt 273.33.
C 70.31%, H 7.01%, N 5.12%, O 17.56%.
Description and references
Prepd by the condensation of anisaldehyde and glycine: Read, Campbell, J. Chem. Soc. 1930, 2676; Lespagnol, Pharmacie Chimique (Paris, 3rd ed., 1950) p 695.
Derivative
dl-Form.Properties
Glistening prisms from alcohol, mp 135.5°. Sol in ethyl acetate.Derivative
dl-Form hydrochloride.Nomenclature
LC-2; Evaclin.Properties
Crystals, dec about 200°. Sol in water.Derivative
l-Form.Properties
Needles from abs alcohol, mp 111-112°. [α]D20 150° (c = 0.952 in abs alcohol).Derivative
l-Form hydrochloride.Properties
Crystals from ethyl acetate, dec 188-190°. [α]D20 99.0° (c = 0.5805). Sol in water.Therapeutic Category
Analgesic.
Keywords
Analgesic (Non-Narcotic)
Status
This monograph has been retired and is no longer subject to revision or update.