12-05583. Lochneridine [Archived]

Nomenclature

CAS number: 5980-01-8
(20α)-2,16-Didehydro-20-hydroxycuran-17-oic acid methyl ester.
C20H24N2O3; mol wt 340.42.
C 70.56%, H 7.11%, N 8.23%, O 14.10%.

Description and references

From Vinca rosea Linn., Apocynaceae: Svoboda et al., J. Pharm. Sci. 50, 409 (1961). Structure: Nakagawa et al., Chem. Ind. (London) 1962, 1986.

Chemical structure

Properties

Prisms from methanol, dec 211-214°. [α]D26 +607.5° (chloroform). pKa 5.5 in 66% DMF. uv max (ethanol): 230, 293, 328 nm (log ε 4.04, 3.94, 4.07).

Status

This monograph has been retired and is no longer subject to revision or update.