12-05810. Mebiquine [Archived]

Nomenclature

CAS number: 23910-07-8
8-[(Dihydroxybismutho)oxy]-6-methylquinoline; dihydroxy(6-methyl-8-quinolinolato)bismuth; 6-methyl-8-bismuthohydroxyquinoline; DV1; Diarétyl.
C10H10BiNO3; mol wt 401.17.
C 29.94%, H 2.51%, Bi 52.09%, N 3.49%, O 11.96%.

Description and references

Prepn by the addition of 6-methyl-8-hydroxyquinoline to a solution of bismuth nitrate: Riviere et al., DE 1811581; eidem, US 3591591 (1969, 1971 to Ugine Kuhlmann). Parasiticidal properties: R. Cavier et al., Ann. Pharm. Fr. 31, 273 (1973).

Chemical structure

Properties

Yellow powder, insol in water, alc, weak alkaline solns. Sol in strong acids. LD50 orally in mice: >10,000 mg/kg (Cavier).

Therapeutic Category

Antidiarrheal.

Keywords

Antidiarrheal

Status

This monograph has been retired and is no longer subject to revision or update.