12-05822. Mecloralurea [Archived]

Nomenclature

CAS number: 1954-79-6
N-Methyl-N′-(2,2,2-trichloro-1-hydroxyethyl)urea; trichloroethylolmethylurea; Heraldium (Sanofi).
C4H7Cl3N2O2; mol wt 221.47.
C 21.69%, H 3.19%, Cl 48.02%, N 12.65%, O 14.45%.

Description and references

Prepn from chloral hydrate and N-methylurea: Chattaway, James, J. Chem. Soc. 1934, 109; FR M5341; GB 1129437 corresp to Castaigne, US 3510557 (1967, 1968 and 1970 to Centre d'Etudes l'Ind. Pharm.).

Chemical structure

Properties

White crystalline powder from boiling water, mp 135-140°. Partly sol in water, acetic acid, ether; sol in alcohol, pyridine. Practically insol in hydrocarbons and chloroform.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic

Status

This monograph has been retired and is no longer subject to revision or update.