12-06350. Morclofone [Archived]

Nomenclature

CAS number: 31848-01-8
(4-Chlorophenyl)[3,5-dimethoxy-4-[2-(4-morpholinyl)ethoxy]phenyl]methanone; 4′-chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone; dimeclophenone; K-3712; Medicil (Medici); Nitux (Inpharzam); Plausitin (Erba).
C21H24ClNO5; mol wt 405.87.
C 62.14%, H 5.96%, Cl 8.74%, N 3.45%, O 19.71%.

Description and references

Prepn: F. Lauria et al., DE 2016707 corresp to US 3708482 (1971, 1973 both to Carlo Erba). Antitussive activity in humans: E. Bosisio et al., Farmaco Ed. Prat. 26, 356 (1971).

Chemical structure

Properties

Cryst from cyclohexane, mp 91-92°. LD50 orally in mice: 552 mg/kg (Lauria).

Therapeutic Category

Antitussive.

Keywords

Antitussive

Status

This monograph has been retired and is no longer subject to revision or update.