12-06347. Moquizone [Archived]

Nomenclature

CAS number: 19395-58-5
2,3-Dihydro-1-[(4-morpholinyl)acetyl]-3-phenyl-4(1H)-quinazolinone; Rec-14-0127.
C20H21N3O3; mol wt 351.40.
C 68.36%, H 6.02%, N 11.96%, O 13.66%.

Description and references

Prepn: G. Bonola et al., J. Med. Chem. 11, 1136 (1968); eidem, ZA 68 03948 C.A. 71, 81406c (1969) and CH 474524; eidem, US 3637681 (1968, 1969, 1972 all to SECEPH). Pharmacology: I. Setnikar et al., Arzneim.-Forsch. 22, 1894 (1972). Toxicology: I. Setnikar, V. De Fina, Toxicol. Appl. Pharmacol. 16, 571 (1970). Review of pharmacological and clinical aspects: F. Grossi, S. Spada, Clin. Ter. 50, 203 (1969).

Chemical structure

Properties

Crystals from isopropanol, mp 135-137°. Crystals from ethyl acetate or benzene-petr ether, mp 128-130°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 19395-78-9
Peristil (Recofarma).
C20H21N3O3.HCl; mol wt 387.86.
C 61.93%, H 5.72%, N 10.83%, O 12.38%, Cl 9.14%.

Properties

Crystals from ethanol-ether, mp 210-214°. Solubility in water (25°): 12.2 g/100 ml. LD50 in mice, rats, rabbits (mg/kg): 1155, 2135, 1650 orally; 237, 146, 180 i.v.; in mice (mg/kg): 774 s.c., 559 i.p. (Setnikar, De Fina).

Therapeutic Category

Choleretic.

Keywords

Choleretic

Status

This monograph has been retired and is no longer subject to revision or update.