12-07040. Oxaflumazine [Archived]

Nomenclature

CAS number: 16498-21-8
10-[3-[4-[2-(1,3-Dioxan-2-yl)ethyl]-1-piperazinyl]propyl]-2-(trifluoromethyl)-10H-phenothiazine.
C26H32F3N3O2S; mol wt 507.61.
C 61.52%, H 6.35%, F 11.23%, N 8.28%, O 6.30%, S 6.32%.

Description and references

Prepn: Ratouis, Boissier, Bull. Soc. Chim. Fr. 1966, 2963; eidem, DE 1911719 (1969 to S.I.F.A.), C.A. 72, 55480y (1970). Pharmacology: Boissier, Dumont, Therapie 26, 481 (1971). Metabolism: Boissier et al., Ann. Pharm. Fr. 30, 851 (1972). Clinical studies: Deniker et al., Therapie 26, 227 (1971).

Chemical structure

Derivative

Disuccinate.

Nomenclature

CAS number: 7450-97-7
SD-270-31; Oxaflumine (Diamant).
C26H32F3N3O2S.2C4H6O4; mol wt 743.79.
C 54.90%, H 5.96%, F 7.66%, N 5.65%, O 21.51%, S 4.31%.

Properties

Crystals from acetonitrile, mp 136-138°. uv max (methanol): 259, 310 nm (log ε 4.53, 3.58). LD50 in mice (mg/kg): 94 i.v.; 175 i.p.; 919 orally (Boissier, Dumont).

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines

Status

This monograph has been retired and is no longer subject to revision or update.