13-06977. Oxaflozane [Archived]

Nomenclature

CAS number: 26629-87-8
4-(1-Methylethyl)-2-[3-(trifluoromethyl)phenyl]morpholine; 4-isopropyl-2-(α,α,α-trifluoro-m-tolyl)morpholine; tetrahydro-4-isopropyl-2-[3-(trifluoromethyl)phenyl]-2H-oxazine.
C14H18F3NO; mol wt 273.29.
C 61.53%, H 6.64%, F 20.86%, N 5.13%, O 5.85%.

Description and references

Non-tricyclic antidepressant agent. Prepn: R. Y. Mauvernay et al., FR 1564792; eidem, US 3637680 (1969, 1972 both to CERM); N. Busch et al., Eur. J. Med. Chem. - Chim. Ther. 11, 201 (1976). Improved synthesis: P. M. Weintraub et al., J. Org. Chem. 45, 4989 (1980). Pharmacological profile: J. Hache et al., Therapie 29, 81 (1974). Urinary metabolism: M. Constantin, J. F. Pognat, Arzneim.-Forsch. 29, 109 (1979). Preliminary clinical study: A. Rascol et al., Therapie 29, 95 (1974).

Chemical structure

Properties

Oil, bp0.005 52°; bp3 99°. nD24 1.4751.

Derivative

Hydrochloride.

Nomenclature

CAS number: 26629-86-7
CERM-1766; Conflictan (Riom).
C14H18F3NO.HCl; mol wt 309.75.
C 54.29%, H 6.18%, F 18.40%, N 4.52%, O 5.17%, Cl 11.45%.

Properties

Crystals from ethyl acetate/ethanol, mp 164°. LD50 in mice (mg/kg): 365 orally, 90 i.v. (Mauvernay, 1969); also reported as: 420 orally, 80 i.v. (Hache).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant

Status

This monograph has been retired and is no longer subject to revision or update.