Nomenclature
CAS number: 973-53-5
[2
S-(2α,5α,6β)]-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid calcium salt (2:1); benzylpenicillin calcium; calcium penicillin G; calcium benzylpenicillinate; benzylpenicillinic acid calcium salt.
C
32H
34CaN
4O
8S
2; mol wt 706.84.
C 54.37%, H 4.85%, Ca 5.67%, N 7.93%, O 18.11%, S 9.07%.
(C
16H
17N
2O
4S)
2Ca.
Description and references
Antibiotic obtained by extraction of an ether
soln of the free acid (prepared from the sodium salt) with satd calcium
hydroxide soln to pH 6.5, followed by lyophilizing: Clarke et
al., Chemistry of Penicillin (Princeton, 1949) p 88.
Properties
White powder, granules, scales. Freely sol in
water, in isotonic sodium chloride soln, in glucose solns. Also sol
in alcohol, glycerol, acetone, ethyl acetate, chloroform. Insol in
fixed oils, liquid petrolatum. pH of an aq soln contg 20,000 units
per ml is 5.0 to 6.5.Therapeutic Category
Antibacterial.
Therapeutic Category (Veterinary)
Antibacterial.
Keywords
Antibacterial (Antibiotics); β-Lactams; Penicillins
Status
This monograph has been retired and is no longer subject
to revision or update.