12-08057. Propyromazine [Archived]

Nomenclature

CAS number: 145-54-0
1-Methyl-1-[1-methyl-2-oxo-2-(10H-phenothiazin-10-yl)ethyl]pyrrolidinium bromide; 1-methyl-1-[1-(phenothiazin-10-ylcarbonyl)ethyl]pyrrolidinium bromide; 10-[2-(1-methyl-1-pyrrolidinyl)propionyl]phenothiazine bromide; 10-[2-(1-pyrrolidinyl)propionyl]phenothiazine methobromide; 10-(2-methyl-1-oxo-2-pyrrolidinylethyl)phenothiazine methobromide; SD-104-19; Diaspasmyl (Aventis).
C20H23BrN2OS; mol wt 419.38.
C 57.28%, H 5.53%, Br 19.05%, N 6.68%, O 3.82%, S 7.65%.

Description and references

Anticholinergic. Prepd by N-acylation of phenothiazine: Boissier et al., Therapie 13, 989 (1958). Prepn of the free base from 10-(α-bromopropionyl)phenothiazine and pyrrolidine: Dahlbom, Ekstrand, Acta Chem. Scand. 5, 102 (1951); eidem, US 2615886 (1952 to Astra).

Chemical structure

Properties

Crystals, mp 228-229°.

Derivative

Free base.
C19H20N2OS; mol wt 324.44.
C 70.34%, H 6.21%, N 8.63%, O 4.93%, S 9.88%.

Properties

Crystals from petr ether, mp 94.5-95.5°.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic; Antimuscarinic

Status

This monograph has been retired and is no longer subject to revision or update.