13-00385. Ambuside [Archived]

Nomenclature

CAS number: 3754-19-6
4-Chloro-6-[(3-hydroxy-2-butenylidene)amino]-N1-2-propenyl-1,3-benzenedisulfonamide; N′-allyl-4-chloro-6-[(3-hydroxy-2-butenylidene)amino]-m-benzenedisulfonamide; 2-(allylsulfamoyl)-5-chloro-4-sulfamoyl-N-(3-hydroxy-2-butenylidene)aniline; 2-allylsulfamyl-4-sulfamyl-5-chloro-N-(3-hydroxy-2-butenylidene)aniline; 5-allylsulfamoyl-2-chloro-4-(3-hydroxybut-2-enylideneamino)benzenesulfonamide; EX-4810; Hydrion (Robert et Carriére).
C13H16ClN3O5S2; mol wt 393.87.
C 39.64%, H 4.09%, Cl 9.00%, N 10.67%, O 20.31%, S 16.28%.

Description and references

Prepn: Robertson, FR 1331680 (1963 to Lakeside), corresp to US 3188329 (1965 to Colgate-Palmolive); Robertson et al., J. Med. Chem. 8, 90 (1965).

Chemical structure

Properties

Crystals, mp 205-207°. uv max: 343 nm (ε 32900).

Therapeutic Category

Diuretic; antihypertensive.

Keywords

Antihypertensive; Sulfonamide Derivatives; Diuretic; Sulfonamide Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.