13-01055. β-Benzalbutyramide [Archived]

Nomenclature

CAS number: 7236-47-7
3-Methyl-4-phenyl-3-butenamide; 3-methyl-4-phenyl-3-butenoic acid amide; β-benzylidenebutyramide; Kata-Lipid (IBI).
C11H13NO; mol wt 175.23.
C 75.40%, H 7.48%, N 7.99%, O 9.13%.

Description and references

Prepn of the acid: Canonica et al., Farmaco Ed. Sci. 14, 112 (1959); Datta, Bagchi, J. Org. Chem. 25, 932 (1960). Clinical studies in atherosclerotic patients: F. Del Regno, G. Capobianco, Minerva Med. 54, 2917 (1963); A. Iacobelli et al., G. Arterioscler. 4, 277 (1966); M. G. Piccardo et al., ibid. 294. Metabolism: L. Canonica et al., J. Biol. Chem. 243, 1645 (1968). Inhibition of cholesterol biosynthesis: D. Giorgini, G. Porcellati, Farmaco Ed. Sci. 24, 392 (1969). Clinical evaluation in hyperlipidemia: U. Marini et al., Farmaco Ed. Prat. 36, 532 (1981).

Chemical structure

Properties

Crystals, mp 132-134°. uv max: 249 nm (log ε 4.1).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic

Status

This monograph has been retired and is no longer subject to revision or update.