13-01063. Benzarone [Archived]

Nomenclature

CAS number: 1477-19-6
(2-Ethyl-3-benzofuranyl)(4-hydroxyphenyl)methanone; 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone; 2-ethyl-3-(4-hydroxybenzoyl)benzofuran; 2-ethyl-3-(p-hydroxybenzoyl)coumarone; L-2197; Fragivix (Sanofi Winthrop); Vasoc (Lindopharm).
C17H14O3; mol wt 266.29.
C 76.68%, H 5.30%, O 18.02%.

Description and references

Prepn: Buu-Hoi, Beaudet, US 3012042 (1961 to Soc. Belge l'Azote Prod. Chim. Marly). Pharmacological studies: Barchewitz et al., Arzneim.-Forsch. 22, 553 (1972). Site of action studies: I. Filipovic, E. Buddecke, ibid. 29, 1578 (1979); L. O. Zwillenberg et al., ibid. 32, 1114 (1982). HPLC determination in serum: H. Vergin, G. Bishop, J. Chromatogr. 183, 383 (1980).

Chemical structure

Properties

Crystals, mp 124.3°.

Therapeutic Category

Capillary protectant.

Keywords

Vasoprotectant

Status

This monograph has been retired and is no longer subject to revision or update.