13-01843. Carbubarb [Archived]

Nomenclature

CAS number: 960-05-4
5-[2-[(Aminocarbonyl)oxy]ethyl]-5-butyl-2,4,6(1H,3H,5H)-pyrimidinetrione; carbamic acid ester with 5-butyl-5-(2-hydroxyethyl)barbituric acid; 5-butyl-5-carbamoyloxyethylbarbituric acid; 5-butyl-5-(2-hydroxyethyl)barbituric acid carbamate; carbamic acid ester with 5-(β-hydroxyethyl)-5-butylmalonylurea; 5-(β-hydroxyethyl)-5-butylmalonylurea carbamate; Nogexan (Farmex).
C11H17N3O5; mol wt 271.27.
C 48.70%, H 6.32%, N 15.49%, O 29.49%.

Description and references

Prepn: FR M1059 (1962 to Consortium Mondial des Grandes Marques), C.A. 59, 7539c (1963); Buzas, US 3150137 (1964). Purification and toxicity: FR M2633 (1964 to Interco Fribourg), C.A. 62, 1671e (1965).

Chemical structure

Properties

Crystals from ethanol, mp 192-194°. LD50 s.c. in mice: 1.4 g/kg (FR M2633).

Note

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Barbituric Acid Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.