13-01857. Carmoxirole [Archived]

Nomenclature

CAS number: 98323-83-2
3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indole-5-carboxylic acid.
C24H26N2O2; mol wt 374.48.
C 76.98%, H 7.00%, N 7.48%, O 8.54%.

Description and references

Selective, presynaptic dopamine D2-receptor agonist. Prepn: H. Bttcher et al., DE 3342632; eidem, US 5256673 (1985, 1993 both to E. Merck); H. Bttcher, R. Gericke, Ann. 1988, 749. Neurochemical profile: A. F. Haase et al., Arch. Pharmacol. 343, 588 (1991). Pharmacology: G. Haeusler et al., Eur. Heart J. 13, Suppl. D, 129 (1992). Pharmacokinetics and clinical evaluation: W. Meyer et al., ibid. 121.

Chemical structure

Properties

Crystals, mp 284-285°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 115092-85-8
EMD-45609.
C24H25N2O2.HCl; mol wt 409.93.
C 70.32%, H 6.39%, N 6.83%, O 7.81%, Cl 8.65%.

Properties

Crystals obtained as 0.25 H2O, mp 298-299°. uv max (methanol): 242, 281 nm.

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Dopamine Receptor Agonist

Status

This monograph has been retired and is no longer subject to revision or update.