13-01871. Caroxazone [Archived]

Nomenclature

CAS number: 18464-39-6
2-Oxo-2H-1,3-benzoxazine-3(4H)-acetamide; 3-acetamide-4H-1,3-benzoxazin-2-one; 4H-3-methylcarboxamide-3-benzoxazine-2-one; 4H-3-carbamoylmethyl-1,3-benzoxazin-2-one; FI-6654; Timostenil (Farmitalia).
C10H10N2O3; mol wt 206.20.
C 58.25%, H 4.89%, N 13.59%, O 23.28%.

Description and references

Prepn: GB 1115759; L. Bernardi et al., US 3427313 (1965, 1969 both to Soc. Farma. Italia); and pharmacological properties: eidem, Experientia 24, 774 (1968). Pharmacology: G. K. Suchowsky, L. Pegrassi, Arzneim.-Forsch. 19, 643 (1969); G. K. Suchowsky et al., Eur. J. Pharmacol. 6, 327 (1969). Clinical study: S. Cecchini et al., J. Int. Med. Res. 6, 388 (1978).

Chemical structure

Properties

Solid, mp 203-205°.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Bicyclics

Status

This monograph has been retired and is no longer subject to revision or update.