13-02090. Chlorazanil [Archived]

Nomenclature

CAS number: 500-42-5
N-(4-Chlorophenyl)-1,3,5-triazine-2,4-diamine; 2-amino-4-(p-chloroanilino)-s-triazine; N-(p-chlorophenyl)-2,4-diamino-s-triazine; 2-(p-chloroanilino)-4-amino-s-triazine; chlorazinil; ASA-226; Diurazine; Triazurol; Orpizin; Neo-Urofort; Neurofort.
C9H8ClN5; mol wt 221.65.
C 48.77%, H 3.64%, Cl 16.00%, N 31.60%.

Description and references

Prepn: Clauder, Bulcsu, Magy. Kem. Foly. 57, 68 (1951), C.A. 46, 4023g (1952); AT 168063 (1951) and GB 676024 (1952), C.A. 47, 8097g, 3887i (1953). Synthesis and diuretic activity: Shah et al., J. Med. Chem. 11, 1167 (1968). See also Takagi, Ueda, Chem. Pharm. Bull. 17, 1061 (1969).

Chemical structure

Properties

Crystals, mp 233-234°. Also reported as crystals from ethanol, mp 256-258° (Shah et al., loc. cit.).

Derivative

Hydrochloride.

Nomenclature

CAS number: 2019-25-2
Daquin (3M Pharma); Doclizid-T; Orpidan (Heumann).
C9H8ClN5.HCl; mol wt 258.11.
C 41.88%, H 3.51%, Cl 27.47%, N 27.13%.

Properties

mp 277-278°.

Therapeutic Category

Diuretic.

Keywords

Diuretic

Status

This monograph has been retired and is no longer subject to revision or update.