13-02404. Clomacran [Archived]

Nomenclature

CAS number: 5310-55-4
2-Chloro-9,10-dihydro-N,N-dimethyl-9-acridinepropanamine; 2-chloro-9-[3-(dimethylamino)propyl]acridan; SKF-14336D.
C18H21ClN2; mol wt 300.83.
C 71.87%, H 7.04%, Cl 11.79%, N 9.31%.

Description and references

Prepn: C. L. Zirkle, US 3131190 (1964 to SKF). Effect on in vivo histamine metabolism: R. Schayer, M. A. Reilly, Arch. Int. Pharmacodyn. Ther. 203, 123 (1973). Clinical potency in relation to dopamine-binding: P. Seeman et al., Nature 261, 717 (1976). Pharmacology: P. Fowler et al., Arzneim.-Forsch. 27, 866 (1977). Photooxidation study: W. R. Knappe, J. Pharm. Sci. 67, 318 (1978).

Chemical structure

Derivative

Phosphate.

Nomenclature

CAS number: 22199-46-8
SKF-14336; Devryl (SK & F); Olaxin (SK & F).
C18H21ClN2.H3PO4; mol wt 398.82.
C 54.21%, H 6.07%, Cl 8.89%, N 7.02%, P 7.77%, O 16.05%.

Properties

LD50 in rats, mice (mg/kg): 350, 222 orally (Fowler).

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Other Tricyclics

Status

This monograph has been retired and is no longer subject to revision or update.