13-02415. Clonitazene [Archived]

Nomenclature

CAS number: 3861-76-5
2-[(4-Chlorophenyl)methyl]-N,N-diethyl-5-nitro-1H-benzimidazole-1-ethanamine; 2-p-chlorobenzyl-1-(2-diethylaminoethyl)-5-nitrobenzimidazole; 1-(β-diethylaminoethyl)-2-p-chlorobenzyl-5-nitrobenzimidazole.
C20H23ClN4O2; mol wt 386.88.
C 62.09%, H 5.99%, Cl 9.16%, N 14.48%, O 8.27%.

Description and references

Prepn: Hunger et al., Experientia 13, 400 (1957); Hoffmann et al., US 2935514 (1960 to Ciba).

Chemical structure

Properties

Crystals, mp 75-76°.

Derivative

Hydrochloride.
C20H23ClN4O2.HCl; mol wt 423.34.
C 56.74%, H 5.71%, Cl 16.75%, N 13.23%, O 7.56%.

Properties

mp 238-240°.

Derivative

Methanesulfonate.
C20H23ClN4O2.CH3SO3H; mol wt 482.98.
C 52.22%, H 5.63%, Cl 7.34%, N 11.60%, O 16.56%, S 6.64%.

Properties

mp 163-166°.

Note

This is a controlled substance (opiate): 21 CFR, 1308.11.

Therapeutic Category

Analgesic (narcotic).

Keywords

Analgesic (Narcotic)

Status

This monograph has been retired and is no longer subject to revision or update.