13-02615. Crimidine [Archived]

Nomenclature

CAS number: 535-89-7
2-Chloro-N,N,6-trimethyl-4-pyrimidinamine; 2-chloro-4-(dimethylamino)-6-methylpyrimidine; W-491; Castrix.
C7H10ClN3; mol wt 171.63.
C 48.99%, H 5.87%, Cl 20.66%, N 24.48%.

Description and references

Prepd from an appropriate 2,4-dihalopyrimidine and dimethylamine: Westphal, US 2219858 (1940 to Winthrop). Toxicology study: K. P. DuBois, J. Am. Pharm. Assoc. Sci. Ed. 37, 307 (1948). Study of pyridoxine as antidote: O. Karlog, E. Knudsen, Nature 200, 790 (1963). HPLTC determn in biological samples: P. De Saqui-Sannes et al., J. Anal. Toxicol. 20, 185 (1996).

Chemical structure

Properties

Commercial product is a brown waxy solid, mp 87°. Practically insol in water. Sol in most organic solvents. Poisonous! LD50 in rats, mice, guinea pigs (mg/kg): 1.00 ±0.06, 0.42 ±0.05, 2.66 ±0.10 i.p.; in rats (mg/kg): 1.25 ±0.10 orally (DuBois). LD50 in male, female mice (mg/kg): 1.3, 1.1 s.c.; in female mice (mg/kg): 1.2 orally (Karlog, Knudsen).

Caution

May cause serious CNS damage leading to fatal convulsions.

Use

Rodenticide.

Status

This monograph has been retired and is no longer subject to revision or update.