13-02882. Defosfamide [Archived]

Nomenclature

CAS number: 3733-81-1
N,N-Bis(2-chloroethyl)-N′-(3-hydroxypropyl)phosphorodiamidic acid 2-chloroethyl ester; 2-chloroethyl N,N-bis(2-chloroethyl)-N′-(3-hydroxypropyl)phosphorodiamidate; N,N,O-tris(2-chloroethyl)-N′-(3-hydroxypropyl)phosphoric acid diamide; desmofosfamide; B-612.
C9H20Cl3N2O3P; mol wt 341.60.
C 31.64%, H 5.90%, Cl 31.14%, N 8.20%, O 14.05%, P 9.07%.

Description and references

Prepn: Arnold et al, DE 1061780 (1959 to Asta-Werke).

Chemical structure

Properties

Oily liquid. Sp gr 1.3675. Practically insol in water. Sol in organic solvents.

Therapeutic Category

Antineoplastic.

Status

This monograph has been retired and is no longer subject to revision or update.